Development and Validation of an Oxidative Phosphorylation-Related Gene Signature in Lung Adenocarcinoma

Abstract

<b>Aim:</b> To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD). <b>Materials & methods:</b> We split The Cancer Genome Atlas LUAD cohort into a training set and a test set; we used the least absolute shrinkage and selection operator Cox method to structure the OXPHOS-related prognostic signature in the training set and verified in the test set and GSE30219 dataset. Meanwhile, the diagnostic model was constructed using the logistic Cox method. <b>Results:</b> The signature consisted of seven genes (<i>LDHA</i>, <i>CFTR</i>, <i>HSPD1</i>, <i>SNHG3</i>, <i>MAP1LC3C</i>, <i>COX6B2</i>, and <i>TWIST1</i>). LUAD patients were divided into high- and low-risk groups, demonstrating good diagnostic and prognostic capabilities. <b>Conclusion:</b> We developed the first-ever OXPHOS-related signature with both prognostic predictive power and diagnostic efficacy.