Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells

Abstract

Collectively, we demonstrated that HuAECs acted as a permissive niche in facilitating expansion of HSPCs. Our study further implicated that the crucial factors and related pathways presented in HuAECs may give a hint to maintain self-renewal of bona fide HSCs.