Intratumoral TIGIT⁺ CD8⁺ T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer

Abstract

Intratumoral TIGIT⁺ CD8⁺ T-cell abundance could serve as an independent prognosticator for clinical outcome and a predictive biomarker for inferior ACT responsiveness. Intratumoral TIGIT⁺ CD8⁺ T-cell abundance correlated with dampened CD8⁺ T-cell antitumor immunity and immunosuppressive contexture abundance, highlighting a tumor-promoting role of TIGIT⁺ CD8⁺ T-cells.