CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer - Concepedia

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CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer

116

Citations

14

References

2020

Year

Jin Huang, Pan Chen, Ke Liu, Jiao Liu, Runliu Wu, Peng Qiu, Zexian Liu, Changfeng Li, Guido Kroemer, Michael T. Lotze,

Abstract

CDK1/2/5 kinase activity is essential for IFNG-mediated cancer immunoevasion. CDK1/2/5 inhibition by dinaciclib provides a novel strategy to overcome IFNG-triggered acquired resistance in pancreatic tumour immunity.

References

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