Planning dosimetry for ⁹⁰Y radioembolization with glass microspheres: Evaluating the fidelity of ^99mTc‐MAA and partition model predictions

Abstract

The unconditional use of ^99m Tc-MAA to predict ⁹⁰ Y dosimetry across all cases is not recommended due to: (a) demonstrated the risk of unmatched catheter positions between procedures, and (b) large bias and uncertainty in ^99m Tc-MAA predictions in cases with matched catheter locations. However, NL voxel dose predictions with ^99m Tc-MAA are clinically viable and either PM or voxel dosimetry can be used to produce equivalent predictions. Both ^99m Tc-MAA and PM can provide tumor dose predictions with potential clinical utility, but only in catheter-matched cases and with tumors comprising a clear majority (>80%) of the total tumor volume. These findings stratify the predictive fidelity of ^99m Tc-MAA- and PM-based treatment planning for ⁹⁰ Y dosimetry in improving treatment outcomes.