<p>Inhibition of PI3K-AKT Signaling Blocks PGE<sub>2</sub>-Induced COX-2 Expression in Lung Adenocarcinoma</p>

Abstract

Simultaneous targeting of COX-2 and PI3K-AKT effectively suppressed PGE₂-induced cell proliferation and migration and both acted in a synergistic manner. Targeting the COX-2-PGE₂ positive feedback loop may be therapeutically beneficial to lung adenocarcinoma.