Science Advances · 2020 · 273 citations · 18 references
Life SciencesImmunologyPharmaceuticsDrug DeliveryInflammationInnate ImmunityCytokine BiologyCytokine-based TherapyInflammatory SignalingIntracellular Drug DeliveryMacrophage BiologyRenal InflammationAnti-inflammatory TherapeuticsExtracellular Vesicle TherapyExtracellular VesiclesIschemic Acute Kidney InjuryM2 Macrophage PhenotypesMacrophage EngineeringMacrophage PolarizationMammalian Target Of Rapamycin Signaling
EVs efficiently drove M2 macrophage polarization by targeting macrophages in the tubulointerstitium. Our study demonstrates that EVs can serve as a promising delivery platform to manipulate IL-10 for the effective treatment of ischemic AKI.
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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
Wai‐Ki Ip, Namiko Hoshi, Dror S. Shouval et al. · Science · 2017 · 1.4K citations · Full text
Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain
Dongfen Yuan, Yuling Zhao, William A. Banks et al. · Biomaterials · 2017 · 596 citations
Autophagy in proximal tubules protects against acute kidney injury
Man Jiang, Qingqing Wei, Guie Dong et al. · Kidney International · 2012 · 470 citations · Full text
Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury
Lin‐Li Lv, Feng Ye, Min Wu et al. · Cell Death and Differentiation · 2019 · 431 citations · Full text
Medicine, Immunology, Nephrology +14