Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom <i>Humphreya endertii</i>

Abstract

Two new lanostane triterpnenoids named endertiins A and B (<b>1</b> and <b>2</b>) together with two known compounds as ganodecalone A (<b>3</b>) and ergosterol (<b>4</b>) have been successfully isolated from the cultivated fruit bodies of the mushroom <i>Humphreya endertii</i> Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B (<b>1</b> and <b>2</b>) were evaluated their cytotoxicity against two cancer cell lines, MCF7 (human breast carcinoma) and LU (human lung carcinoma). The result showed that endertiin A (<b>1</b>) could inhibit the growth of MCF-7 cells with its IC₅₀ value of 71.16 ± 6.25 µg/ml.