Concepedia

15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling

Suzu Endo, Akiko Suganami, Keijo Fukushima, Kanaho Senoo, Yumi Araki, John W. Regan, Masato Mashimo, Yutaka Tamura, Hiromichi Fujino

Journal of Biological Chemistry · 2020 · 20 citations · 20 references

DOIFull text

Open access

Concepts

Abstract

-evoked inflammation and/or maintaining homeostasis of colorectal tissues/cells functions.

References

20

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

Marc van de Wetering, Elena Sancho, Cornelis L. Verweij et al. · Cell · 2002 · 2K citations · Full text

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Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

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The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Mark Abramovitz, Mohammed Adam, Yves Boie et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2000 · 557 citations · Full text

, , +10

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin, Christian Watson, Vanessa Muniz‐Medina et al. · ACS Chemical Neuroscience · 2011 · 486 citations

, , +17

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

Kenji Kabashima, Tomomi Saji, Miyako Nagamachi et al. · Journal of Clinical Investigation · 2002 · 442 citations · Full text

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