Clostridiales are predominant microbes that mediate psychiatric disorders

Abstract

Our study revealed common microbial shift patterns across psychiatric disorders and found predominant psychiatry-associated intestinal microbes and functions. Depletion of Clostridiales (e.g., Roseburia) probably mediated different psychiatric diseases by dysfunction of intestinal amino acid metabolism and SCFA production. Furthermore, our study indicated that correlations of microbial shift patterns between psychiatric diseases may derived from their genetic associations. Such shared microbial dysbiosis patterns are intriguing for discovering biomarkers and investigating therapeutic targets for treating psychiatric diseases.