Regioselective Halogenation of 2 <i>H</i> ‐Chromenones Promoted by Oxone and NaX: A Facile Approach for the Preparation of Halochromenones and 2 <i>H</i> ‐Chromenone Natural Products

Abstract

Abstract A systematic study has been conducted for the regioselective halogenation of 2 H ‐chromenones to prepare 3‐halo‐2 H ‐chromenones, 4‐substituted 3‐halo‐2 H ‐chromenones and 3‐(2‐haloacetyl)‐2 H ‐chromenones. Commercially available NaCl/NaBr has been used as halogen source and oxone as an oxidant to produce the compounds. Further, the method has been successfully applied for the preparation of pharmaceutically important halogenated 2 H ‐chromenone natural products. The present approach is simple, economically viable and provided the target compounds with good yields.