NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

Inflammation, Signal Transduction, Signaling Pathway +12

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.5K citations

Inflammation, Anti-inflammatory, Signal Transduction +8

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.1K citations · Full text

Inflammation, Apoptosis, Cell Death +7

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Edward A. Miao, Irina A. Leaf, Piper M. Treuting et al. · Nature Immunology · 2010 · 1.3K citations · Full text

Inflammation, Virulence Factor, Apoptosis +13

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Yue Zhao, Jieling Yang, Jianjin Shi et al. · Nature · 2011 · 1.2K citations

Bacterial Flagellin, Protein Secretion, Nlrc4 Inflammasome Receptors +9