Concepedia

Overexpression of P‐glycoprotein and resistance to Imatinib in chronic myeloid leukemia patients

Mariam Ammar, Nour Louati, Imen Frikha, Moez Medhaffar, H. Ghozzi, Moez Elloumi, Héla Menif, Khaled Zeghal, Lobna Ben Mahmoud

Journal of Clinical Laboratory Analysis · 2020 · 30 citations · 29 references

DOIFull text

Open access

Abstract

The overexpression of P-gp on lymphocytes has significantly correlated with the failed molecular response to IM in patients with CML.

References

29

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

Moshe Talpaz · Blood · 2002 · 1K citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

JE Sokal, Cox Eb, Michele Baccarani et al. · Blood · 1984 · 1K citations · Full text

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

JE Sokal, Cox Eb, Michele Baccarani et al. · Blood · 1984 · 954 citations

Active transport of imatinib into and out of cells: implications for drug resistance

Julia Thomas, Lihui Wang, Richard E. Clark et al. · Blood · 2004 · 640 citations · Full text

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

François‐Xavier Mahon, Françis Belloc, Valérie Lagarde et al. · Blood · 2003 · 537 citations · Full text