Critical Care Medicine · 2017 · 3.7K citations · 471 references
Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
471
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer, Clifford S. Deutschman, Christopher W. Seymour et al. · JAMA · 2016 · 26.3K citations · Full text
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon Guyatt, Andrew D Oxman, Gunn Elisabeth Vist et al. · BMJ · 2008 · 20.6K citations · Full text
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
Emanuel P. Rivers, Bryant Nguyen, Suzanne Havstad et al. · New England Journal of Medicine · 2001 · 10.7K citations · Full text
Intensive Insulin Therapy in Critically Ill Patients
Greet Van den Berghe, Pieter Wouters, Frank Weekers et al. · New England Journal of Medicine · 2001 · 10K citations · Full text