Concepedia

Enhancing chimeric antigen receptor T‐cell immunotherapy against cancer using a nanoemulsion‐based vaccine targeting cross‐presenting dendritic cells

Jack D. Chan, Bianca von Scheidt, Bijun Zeng, Amanda J. Oliver, Ashleigh S Davey, Aesha I. Ali, Ranjeny Thomas, Joseph A. Trapani, Phillip K. Darcy, Michael H. Kershaw,

Clinical & Translational Immunology · 2020 · 38 citations · 25 references

DOIFull text

Open access

Abstract

Our study presents Clec9A-TNE as a prospective avenue to enhance CAR T-cell efficacy for solid cancers.

References

25

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

Stephan A. Grupp, Michael Kalos, David M. Barrett et al. · New England Journal of Medicine · 2013 · 3.4K citations · Full text

, , +18

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.8K citations

, , +7

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- <i>scid IL2R</i> γ <i>null</i> Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Leonard D. Shultz, Bonnie Lyons, Lisa Burzenski et al. · The Journal of Immunology · 2005 · 1.7K citations · Full text

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Megan Barnden, Jan Allison, William R. Heath · Immunology and Cell Biology · 1998 · 1.5K citations

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

James N. Kochenderfer, Wyndham H. Wilson, John E. Janik et al. · Blood · 2010 · 1.3K citations · Full text