Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts

Abstract

This study shows that a significant therapeutic ratio can be achieved by a low dose of Hsp90 inhibitor in combination with radiotherapy. Hsp90 inhibition, even at a low dose, can be monitored by measuring Hsp70 expression in PBMCs in human studies.

References

Page 1

	Year	Citations
Evaluation of survival data and two new rank order statistics arising in its consideration. Nathan Mantel PubMed Prognostic EvaluationLongevitySurvival DataPrognosisRare Event Estimation	1966	7.6K
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. PubMed Laboratory HematologyMonuclear CellsGranulocyteImmunologyHematology	1968	5.3K
MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes Graeme C. McAlister, David P. Nusinow, Mark P. Jedrychowski, Analytical Chemistry Molecular BiologyChemical BiologyCancer BiologyTumor BiologyProteomic Technology	2014	1.3K
Heat shock proteins as regulators of the immune response A. Graham Pockley The Lancet InflammationHost ResponseHeat Shock ProteinsImmune RegulationImmunology	2003	696
Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves Bernard Fertil, H. Dertinger, A. Courdi, Radiation Research Radiation EffectRadiation ExposurePathologyUseful ConceptLongevity	2012	355
Mean Inactivation Dose: A Useful Concept for Intercomparison of Human Cell Survival Curves Bernard Fertil, H. Dertinger, A. Courdi, Radiation Research	1984	297
An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine Pablo C. Echeverría, Andreas Bernthaler, Pierre Dupuis, PLoS ONE EngineeringGeneticsInteraction NetworkMolecular BiologyPublic Data	2011	257
Abnormal RNA stability in amyotrophic lateral sclerosis EM Tank, Claudia Figueroa‐Romero, Lucy M. Hinder, Nature Communications	2018	154
Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia Jeffrey E. Lancet, Ivana Gojo, Michael Burton, Leukemia Hematological MalignancyOncologyHeat ShockAcute Myeloid LeukemiaPharmacology	2010	154
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase Elana S. Ehrlich, Tao Wang, Kun Luo, Proceedings of the National Academy of Sciences Hsp90 Chaperone ComplexProtein FunctionHsp90 ClientHsp90 Client RegulationMolecular Regulation	2009	119

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