Concepedia

Tumor Microenvironment-triggered Nanosystems as dual-relief Tumor Hypoxia Immunomodulators for enhanced Phototherapy

Zijun Shen, Junfei Xia, Qingming Ma, Wei Zhu, Zhen Gao, Shangcong Han, Yan Liang, Jie Cao, Yong Sun

Theranostics · 2020 · 100 citations · 40 references

DOIFull text

Open access

Concepts

Abstract

The proposed novel nanosystems represent an important advance in altering TME for improved clinical PDT efficacy, as well as their potential as effective theranostic agents in cancer treatment.

References

40

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO<sub>2</sub>‐Based Nanoagent to Enhance Chemodynamic Therapy

Lisen Lin, Jibin Song, Liang Song et al. · Angewandte Chemie International Edition · 2018 · 1.5K citations

, , +17

In Vitro Demonstration of the Heavy-Atom Effect for Photodynamic Therapy

Aoife Gorman, J. Killoran, Caroline O'Shea et al. · Journal of the American Chemical Society · 2004 · 898 citations

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H<sub>2</sub>O<sub>2</sub>-Activatable and O<sub>2</sub>-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

Huachao Chen, Jiangwei Tian, Weijiang He et al. · Journal of the American Chemical Society · 2015 · 806 citations

, , +17

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

Manli Song, Ting Liu, Changrong Shi et al. · ACS Nano · 2015 · 654 citations · Full text

, , +17

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

Conghui Liu, Dongdong Wang, Shuyuan Zhang et al. · ACS Nano · 2019 · 649 citations

, , +17