The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

Abstract

In newly diagnosed stage IV melanoma patients S-100B correlates with ¹⁸F-FDG PET/CT derived MATV and TLG in contrast to LDH, is more often elevated than LDH (71% vs. 21%) and seems to be a better predictor of disease load and disease progression. However, elevated LDH is the only predictor for survival. The biomarkers, S-100B and LDH appear to describe different aspects of the extent of metastatic disease and of tumornecrosis.