Nicotine increases alcohol self‐administration in male rats via a μ‐opioid mechanism within the mesolimbic pathway

Abstract

Collectively, these results suggest that nicotine contributes to escalate alcohol self-administration through a dysregulation of μ receptor activity in the VTA. These data imply that targeting μ rather than κ receptors may be the preferred pharmacotherapeutic approach for the treatment of alcohol use disorder when nicotine use contributes to alcohol consumption.