Concepedia

The PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in chronic obstructive pulmonary disease caused by PM2.5 particulate matter

Fang Zhang, Hui Ma, Zhong Lan Wang, Wei Li, Hua Liu, Yan Xia Zhao

Journal of International Medical Research · 2020 · 57 citations · 13 references

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Abstract

These data demonstrate that PI3K/AKT/mTOR pathway regulates autophagy to induce apoptosis of alveolar epithelial cells in COPD.

References

13

PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells

Xiaobei Deng, Rui Wei, Fang Zhang et al. · Cell Biology and Toxicology · 2013 · 227 citations

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MTOR Suppresses Cigarette Smoke–Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease

Yong Wang, Juan Liu, Jie-Sen Zhou et al. · The Journal of Immunology · 2018 · 96 citations

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle

Olivier Roger Joassard, Adel Amirouche, Yann S. Gallot et al. · The International Journal of Biochemistry & Cell Biology · 2013 · 66 citations

, , +12

The effects of autophagy on vascular endothelial cells induced by airborne PM2.5

Zhixiang Zhou, Tong Shao, Mengnan Qin et al. · Journal of Environmental Sciences · 2017 · 65 citations

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Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway

Qiang Wan, Zhongyong Liu, Yuping Yang · BMC Complementary and Alternative Medicine · 2018 · 53 citations · Full text