Syntheses, characterization and crystal structures of fluorine substituted Schiff base copper(II) and nickel(II) complexes with biological activity

Abstract

Two copper(II) complexes, [Cu2(L1)2]·2H2O (1) and [Cu3(L1)2(NCS)2] (2), and two nickel(II) complexes, [NiL2(NCS)] (3) and [Ni(L2)2(NCS)]·CH3OH (4), were prepared from the fluorine substituted Schiff bases N,N'-bis(4-fluorosalicylidene)-1,2-diaminopropane (H2L1) and 4-fluoro-2-[(2-isopropylaminoethylimino)methyl]phenol (HL2), respectively. The compounds were characterized by physico-chemical methods. Structures of the complexes were further confirmed by single crystal X-ray diffraction. The Cu ions in 1 are square pyramidal, and in 2 are square planar and octahedral. The Ni ion in 3 is square planar, and in 4 is octahedral. All the complexes have effective Jack bean urease inhibitory activities. Complex 1 has the most effective activity, with an IC50 value of 2.1 ± 1.3 μmol L−1.