Advances in Decarboxylative Palladium-Catalyzed Reactions of Propargyl Electrophiles

Abstract

The propargyl electrophile has proven to be a versatile reactant when coupled with palladium catalysis. Its versatility is owed to the several reaction pathways that the palladium-propargyl intermediate can proceed by, and the outcome can be predictably controlled by varying several factors. The tunable nature of the propargyl electrophile along with its versatility are detailed herein. The initial reports for each of the pathways are highlighted along with a discussion of more recent developments in the field.