Subventricular zone contacting glioblastoma: tumor size, molecular biological factors and patient survival

Abstract

This study confirms SVZ contact at diagnosis as an independent negative prognostic factor for glioblastoma patient survival. SVZ_pos glioblastoma had larger tumor size and a larger proportion of unmethylated tumors than SVZ_neg glioblastoma. Further research is needed to establish whether the observed differences are solely explained by a different molecular profile of SVZ_pos glioblastoma or by interaction of glioblastoma with the unique SVZ microenvironment.