Reduced Susceptibility of <i>Mycobacterium tuberculosis</i> to Bedaquiline During Antituberculosis Treatment and Its Correlation With Clinical Outcomes in China

Abstract

MDR-TB patients in China exhibited a low initial BDQ resistance rate. MDR-TB cases with acquired BDQ resistance were at greater risk of treatment failure relative to initially BDQ-resistant cases. Rv0678 mutations accounted for BDQ resistance in this cohort.