Assessing serum IgG4 glycosylation profiles of IgG4-related disease using lectin microarray

Abstract

Serum IgG4 of IgG4-RD patients exhibits different glycosylation levels. This study demonstrated that there is important clinical value in identifying aberrant GlcNAc levels as a potential diagnostic index for multi-organ involvement. Furthermore, the mannose level of serum IgG4 may reflect the degree of inflammation of IgG4-RD.