General Cu-Catalyzed C_sp–S Coupling

Abstract

Copper-catalyzed cross-coupling of thiols and bromoalkynes affords a mild, rapid, and selective C_sp-S coupling with broad scope, enabling the use of aryl-, alkyl-, and silyl-substituted alkynyl coupling partners (38 total examples, 50-99% yields). Importantly, the method enables the preparation of difficult-to-access bis-heteroatom-functionalized (<i>S</i>,<i>S</i>-, <i>S</i>,<i>P</i>-, and <i>S</i>,<i>N</i>-) alkynes.