Concepedia

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca <sup>2+</sup> transfer for survival

César Cárdenas, Alenka Lovy, Eduardo Silva-Pavez, Félix A. Urra, Craig Mizzoni, Ulises Ahumada-Castro, Galdo Bustos, Fabián Jaña, Pablo Cruz, Paula Farías,

Science Signaling · 2020 · 69 citations · 46 references

DOIFull text

Open access

Concepts

Abstract

transfer may represent a general therapeutic strategy against cancer cells regardless of their OXPHOS status.

References

46

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Cellular Signalling · 2007 · 4.8K citations

, , +14

Methods in Mammalian Autophagy Research

Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell · 2010 · 4.5K citations · Full text

, , +10

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi et al. · Autophagy · 2018 · 2.1K citations · Full text

, , +17

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell et al. · Nature · 2011 · 1.8K citations · Full text

, , +17

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert B. Hamanaka, William W. Wheaton et al. · Proceedings of the National Academy of Sciences · 2010 · 1.7K citations

, , +17