Dual <i>MGMT</i> inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma

Abstract

Our data suggest that the molecular subgroup characterized by the dual inactivation of MGMT receives greater benefit from TMZ treatment. The results of our study may be of immediate clinical interest since chromosome 10q status and methylation of MGMT promoter are commonly determined in routine practice.