Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing<i>IL-1β</i>gene expression in male rats

Abstract

The data demonstrated that the liver levels of the GSH, GPx, SOD, and CAT significantly reduced and the levels of the serum protein carbonyl, AST, ALP, ALT, total bilirubin, MDA, serum IL-1β, and the liver <i>IL-1β</i> gene expression were remarkably increased in the second group compared to control group. On the other hand, treatment with GA led to a significant elevation in GSH, GPx, SOD, CAT, and a significant decrease in protein carbonyl, AST, ALP, ALT, total bilirubin, MDA, serum IL-1β, and gene expression of <i>IL-1β</i> in comparison with the second group. Histological changes were also ameliorated by GA oral administration. <b>Discussion and Conclusions:</b> The data show that the oral administration of GA could alleviate the noxious effects of DIC on the antioxidant defense system and liver tissue.