Concepedia

Venetoclax in association with decitabine as effective bridge to transplant in a case of relapsed early T‐cell lymphoblastic leukemia

Elisabetta Zappone, Emanuele Cencini, Marzia Defina, Anna Sicuranza, Alessandro Gozzetti, Sara Ciofini, Donatella Raspadori, Bianca Mecacci, Monica Bocchia

Clinical Case Reports · 2020 · 31 citations · 12 references

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Concepts

Abstract

A case of an early-relapsed high-risk T-ALL with high BCL-2 expression on leukemic blasts was successfully treated with decitabine and venetoclax, achieving a CR. We suggest decitabine and venetoclax should be synergistic in BCL2-positive ALL.

References

12

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

Andrew W. Roberts, Matthew S. Davids, John M. Pagel et al. · New England Journal of Medicine · 2015 · 1.9K citations · Full text

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Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

Courtney D. DiNardo, Keith W. Pratz, Vinod Pullarkat et al. · Blood · 2018 · 1.9K citations · Full text

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Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

D. Hoelzer, Renato Bassan, Hervé Dombret et al. · Annals of Oncology · 2016 · 455 citations

, , +13

Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Tríona Ní Chonghaile, Justine E. Roderick, Cian Glenfield et al. · Cancer Discovery · 2014 · 274 citations · Full text

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ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie Peirs, Filip Matthijssens, Steven Goossens et al. · Blood · 2014 · 272 citations

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