Antimycotic Activity of Ozonized Oil in Liposome Eye Drops against <i>Candida</i> spp.

Abstract

Purpose: . Methods: ) membrane potential, and the extent of membrane lipid peroxidation. Results: , and increased reactive oxygen species generation. Conclusions: The significant increases in reactive oxygen species production cause the accumulation of reactive oxygen species-associated damages leading to progressive Candida cell dysfunction. Translational Relevance: The antifungal activity of Ozodrop was demonstrated at concentrations several times lower than the concentration that can be retrieved in ocular surface after its application. The antifungal activity of the eye drops Ozodrop would represent an interesting off-label indication for a product basically conceived as an eye lubricant.