Concepedia

VRK-1 extends life span by activation of AMPK via phosphorylation

Sang‐Soon Park, Murat Artan, Hae‐Eun H. Park, Yoonji Jung, Ara B. Hwang, Won‐Sik Shin, Kyong‐Tai Kim, Seung‐Jae Lee

Science Advances · 2020 · 30 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans .

References

29

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

Andrew Dillin, Ao‐Lin Hsu, Nuno Arantes-Oliveira et al. · Science · 2002 · 1.1K citations

, , +17

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Siu Sylvia Lee, Raymond Lee, Andrew Fraser et al. · Nature Genetics · 2002 · 967 citations

, , +16

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

Katja Lamia, Uma M. Sachdeva, Luciano DiTacchio et al. · Science · 2009 · 939 citations · Full text

, , +17

Telomere length in early life predicts lifespan

Britt J. Heidinger, Jonathan D. Blount, Winnie Boner et al. · Proceedings of the National Academy of Sciences · 2012 · 725 citations · Full text

, , +12

Distinct Requirements for Somatic and Germline Expression of a Generally Expressed <i>Caernorhabditis elegans</i> Gene

William G. Kelly, Siqun Xu, Mary K. Montgomery et al. · Genetics · 1997 · 468 citations · Full text

, , +13