High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice

Abstract

Based on the findings of the current study, intranasally or inhalation exposure to high-dose nanosized TiO₂ particles appears to exacerbate the allergic airway inflammation and lead to systemic uptake in extrapulmonary organs. These results indicate the very important need to investigate the upper limit of intranasally or inhalation exposure to nanosized TiO₂ particles in occupational and environmental health policy.