Choline chloride‐urea deep eutectic solvent as an efficient media for the synthesis of propargylamines via organocuprate intermediate

Abstract

A facile method for the synthesis of various propargylamines derivatives with different structural parts has been reported. The reaction has consisted of one‐pot coupling between aldehydes, secondary amines and terminal alkynes using CuCl as a catalyst and choline chloride/urea DES as a cheap and biocompatible reaction media. The procedure is free of using toxic solvents and used CuCl as an available, inexpensive and non‐toxic catalyst. Using this methodology, 15 different propargylamine derivatives were successfully synthesized at 60 °C in 15 hr, mostly in good yields.