Concepedia

Microenvironment in cutaneous melanomas: a gene expression profile study may explain the role of histological regression

Simona Osella‐Abate, Chiara Vignale, Laura Annaratone, Alberto Nocifora, Luca Bertero, Isabella Castellano, Gianluca Avallone, Luca Conti, Pietro Quaglino, Franco Picciotto,

Journal of the European Academy of Dermatology and Venereology · 2020 · 12 citations · 7 references

DOI

Concepts

Abstract

Specific subsets of T-helper lymphocytes have been identified as associated with anergy and impairment of CD8+ immune response against cancer cells. In particular, the immune infiltrate of regressed melanoma has been proven to have lower counts of CD25+/CD4+, FOXP3+/CD4+ and PD1+/CD4+ lymphocytes compared to the non-regressed ones.

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