<scp>NMDAR</scp> Antibodies Alter Dopamine Receptors and Cause Psychotic Behavior in Mice

Abstract

In addition to memory deficits and reduction of NMDARs, CSF antibodies from patients with anti-NMDAR encephalitis cause reversible psychotic-like features accompanied by changes (D1R decrease, D2R increase) in cell-surface dopamine receptor clusters. ANN NEUROL 2020 ANN NEUROL 2020;88:603-613.