Molecular Therapy — Nucleic Acids · 2020 · 52 citations · 31 references
Life SciencesImmunologyMolecular BiologyGene ExpressionMolecular VirologyVirologyAntiviral ImmunityMacrophage BiologyMicrorna-mediated RegulationRna InterferenceViral InfectionsViral PathogenesisBone Marrow - Derived CellsCoxsackievirus InfectionsM2 Macrophage PhenotypesM2-like Macrophage ActivationMacrophage PolarizationMicrorna In InflammationRegulation By Noncoding Ribonucleic AcidViral Myocarditis
mice. Moreover, miR-192 overexpression promoted macrophage M2 polarization in vitro, and interleukin-1 receptor-associated kinase 1 (IRAK1) was identified as a direct target. miR-192 overexpression effectively rescued mice from lethal myocarditis caused by CVB3 infection and switched myocardial-infiltrating macrophages to a predominant M2 phenotype. Collectively, our findings uncover a critical mechanism of AK085865 in the regulation of macrophage polarization in vitro and in vivo and provide a potential, clinically significant therapeutic target.
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Parental imprinting of the mouse H19 gene
Marisa S. Bartolomei, Sharon Zemel, Shirley M. Tilghman · Nature · 1991 · 1.2K citations
A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes
Susan Carpenter, Daniel Aiello, Maninjay Atianand et al. · Science · 2013 · 968 citations · Full text