Organophotoredox-Catalyzed Direct C–H Amination of 2<i>H</i>-Indazoles with Amines

Abstract

A general and practical method for the direct C-H amination of 2<i>H</i>-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2<i>H</i>-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.