Loss-of-Function <i>CREB3L3</i> Variants in Patients With Severe Hypertriglyceridemia

Abstract

Our findings indicate that rare variants in a noncanonical gene for triglyceride metabolism, namely <i>CREB3L3</i>, contribute significantly to severe hypertriglyceridemia. Secondary genes and pathways should be considered when evaluating the genetic architecture of this complex trait.