<p>Piperine Alters the Pharmacokinetics and Anticoagulation of Warfarin in Rats</p>

Abstract

We conclude that piperine could be a potent inhibitor of cytochrome P450 metabolism of warfarin in vivo and, contrary to the expectation, may reduce the plasma concentration and anticoagulation of warfarin. This interaction could have a clinical significance and should be investigated in patients.