Synthesis and bioevaluation of 1-phenylimidazole-4-carboxylic acid derivatives as novel xanthine oxidoreductase inhibitors

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

Cristofer Enroth, B.T. Eger, Ken Okamoto et al. · Proceedings of the National Academy of Sciences · 2000 · 718 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28‐week, phase III, randomized, double‐blind, parallel‐group trial

H. Ralph Schumacher, Michael A. Becker, Robert L. Wortmann et al. · Arthritis Care & Research · 2008 · 631 citations

Pharmacy, Pharmacology, Pharmacotherapy +16

Effect of lowering uric acid on renal disease in the type 2 diabetic<i>db/db</i>mice

Tomoki Kosugi, Takahiro Nakayama, Marcelo Heinig et al. · American Journal of Physiology-Renal Physiology · 2009 · 173 citations · Full text

Medicine, Nephrology, Pharmacology +17

FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase

Koji Matsumoto, Ken Okamoto, Naoki Ashizawa et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 132 citations

Life Sciences, Biochemistry, Pharmacology +13

Synthesis and structure–activity relationships of 1-Phenylpyrazoles as xanthine oxidase inhibitors

Seigo Ishibuchi, Hiroshi Morimoto, Takanori Oe et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 123 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12