Observation of Reduced Homeostatic Metabolic Activity and/or Coupling in White Matter Aging

Abstract

Previous studies have shown that k_po tracks Na⁺ , K⁺ -ATPase activity-dependent water exchange at the BBB and likely reflects neurogliovascular unit (NGVU) coupled metabolic activity. The age-related decline in k_po observed here is consistent with compromised NGVU metabolism in older individuals and the dysregulated cellular bioenergetics that accompany normal brain aging.