Morphological and Transcriptional Changes in Human Bone Marrow During Natural <i>Plasmodium vivax</i> Malaria Infections

Abstract

This study thus shows that during P. vivax infections, parasites are always present in the BM and that such infections induced dyserythropoiesis and ineffective erythropoiesis. Moreover, infections induce transcriptional changes associated with such altered erythropoietic response, thus highlighting the importance of this hidden niche during natural infections.