Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent <i>Plasmodium falciparum</i> infection

Abstract

Monocyte activation during subpatent malaria is driven by an IFN molecular signature with robust activation of genes enriched in pathogen detection, phagocytosis, antimicrobial activity and antigen presentation. The greater magnitude of transcriptional changes in children with acute malaria suggests monocyte phenotypes may change with age or exposure.