Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma

Abstract

High proportions of T lymphocytes and CD45RO⁺ cells were associated with prolonged mPFS and mOS in sarcomatoid patients treated with ICI immunotherapy. These data support the expansion of trials utilizing single and combination ICIs as first-line therapy in sarcomatoid MPM and warrants further studies testing the impact or detriment of chemotherapy pre-ICI.