Syringic Acid Delivered Via mPEG-PLGA-PLL Nanoparticles Enhances Peripheral Nerve Regeneration Effect

Abstract

<b>Aim:</b> To deliver syringic acid (SA) with a nanocarrier and enhance its function. <b>Materials & methods:</b> mPEG-PLGA-PLL (PEAL) nanoparticles were used to deliver SA. The characterization, storage stability, drug release, blood-compatibility and biocompatibility of SA-PEAL were detected by <i>in vitro</i> and <i>in vivo</i> assays. Cellular phenotypic experiments and rat sciatic nerve injury models were used to evaluate the function of SA-PEALs. <b>Results:</b> SA-PEAL had good storage stability, blood-compatibility and biocompatibility and could slowly release SA. SA-PEAL significantly enhanced the proliferation and migration ability of Schwann cells and function recovery of injured sciatic nerves. <b>Conclusion:</b> Our study provides an effective nano-delivery system for enhancing the neural repair function of SA and promoting further applications of SA.