Autoantigen <i>TRIM21</i>/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity

Abstract

What is already known on this subject TRIM21/Ro52 is a major autoantibody target in pSS and regulates downstream signalling of type I IFNs. Apoptosis-associated surface expression of TRIM21 on non-immune cells is associated with enhanced binding of anti-Ro52 autoantibodies.