Stromal LAG-3⁺ cells infiltration defines poor prognosis subtype muscle-invasive bladder cancer with immunoevasive contexture

Abstract

Stromal LAG-3⁺ cells abundance indicated an immunoevasive contexture with dysfunctional CD8⁺ T cells, and represented an independent predictor for adverse survival outcome and ACT resistance in MIBC. LAG-3 expression could potentially be a novel biomarker for FGFR3-targeted and EGFR-targeted therapies and immunotherapy. The crucial role of LAG-3⁺ cells in the therapeutic landscape of MIBC needs further validation retrospectively and prospectively.