Synonymous variants associated with Alzheimer disease in multiplex families

Abstract

These findings suggest that <i>CDH23, SLC9A3R1, RHBDD2</i>, and possibly <i>ITIH2</i>, which are involved in synaptic function, the glutamatergic system, and innate immunity, contribute to AD etiology. In addition, this study supports the notion that synonymous variants contribute to AD risk and that comprehensive scrutinization of this type of genetic variation is warranted and critical.