<scp>Iridium‐Catalyzed</scp> Enantioselective C(sp³)–H Borylation of Cyclobutanes

Abstract

Summary of main observation and conclusion We herein report the first example of iridium‐catalyzed enantioselective C(sp 3 )–H borylation of cyclobutanes using benzoxazoline as the directing group. The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp 3 )–H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities. We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.